by: Carroll W. Frenzel Topics: Information technology -- Management. urn: acs6:managementofinfo00fren_0:epub:e3dbc Management Information Systems. Doc: Management Of Information Technology By Carroll W. Frenzel ePub: Management Of Information. Management of Information Technology 4th edition by Carroll W. Frenzel, John C . Frenzel () Paperback by John C. Frenzel Carroll W.
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Trove: Find and get Australian resources. Books, images, historic newspapers, maps, archives and more. Management Of Information Technology. Carroll W Frenzel. Managing Information Technology (7th Edition): Carol V. Brown As a student in the Management. Find all the study resources for Management of Information Technology by Carroll W Frenzel.
The Web-based application provided a continuous feedback mechanism for patients between visits to their oncologist, which resulted in early detection of complications and signs of relapse for earlier care. Thus, approaches that included monitoring of emerging toxicity prompting the healthcare team to conduct proactive symptom management would be expected to provide value in improving medication adherence in oncology.
Another randomized controlled trial demonstrated higher compliance with using internet follow-up for patients with esophageal cancer. By allowing patients to evaluate their adverse effects on a continual basis, mHealth provides the opportunity to identify and manage toxicities earlier.
Throughout all phases of oncology drug development, the reporting of symptomatic AEs is a crucial component of understanding the efficacy and quality of potential treatments and their impact on patients.
The current method of collecting AEs in oncology clinical trials is based on physician reporting using the Common Terminology Criteria for Adverse Events. Clinicians report AEs from oncology treatment on a scale of can range from 0 to 5, each number representing severity levels of none, mild, moderate, severe, life-threatening, or death, respectively.
An IRB review of mHealth research must address challenges such as the lack of face-to-face interaction, minor consent, responsibility of data integrity, privacy, security, confidentiality, and the collection of unrelated study data eg, geographical location, personal contacts, Internet searches. Currently, systematic reviews and novel methods are being investigated to assess medical apps for clinical safety.
Conclusion As patients advocate for their place in the healthcare system, mHealth provides opportunities and resources for patients and providers to collaborate on healthcare and promote shared decision making for improved health and health outcomes.
However, adoption of this technology requires that patients, providers, and informatics systems align despite the inherent challenges in mHealth adoption, EHR integration, or privacy, security, and condidentiality. As a disruptive technology, mHealth offers an opportunity to improve on the quality and safety of healthcare. Health-related smartphone apps: status update for hem-onc practitioners.
The Hematologist. HIMSS website. Published February 23, Accessed May 1, World Health Organization website. Published Moumtzoglou A. M-health Innovations for patient-centered care. IGI Global. Activating racial and ethnic minorities to engage in preventive health: patient preferences for health reminders.
J Participat Med. Wood WA. Bennett AV, Basch E.
Emerging uses of patient generated health data in clinical research. Mol Oncol.
Ventola CL. Mobile devices and apps for health care professionals: uses and bene ts. Tweeting to health: a novel mHealth intervention using Fitbits and Twitter to foster healthy lifestyles [ePub ahead of print].
Clin Pediatr Phila. J Med Internet Res. Mobile medical and health apps: state of the art, concerns, regulatory control and certi cation. Online J Public Health Inform. In: Waegemann CP, ed. IGI Global; Patient attitudes toward mobile phone-based health monitoring: questionnaire study among kidney transplant recipients.
E ciency, satisfaction, and costs for remote video visits following radical prostatectomy: a randomized controlled trial. Eur Urol. Social media for nurses: educating practitioners and patients in a networked world. The best strategy for raising relaxivity at high field strength is probably a moderate reversible binding to plasma proteins, a large second sphere of water molecules surrounding the Gd-complex, and an increase in q; however, the benefits of the latter modification should be weighed against any reduction in complex stability.
Tissue-specific contrast agents are already available, such as gadoxetic acid, which is taken up by a hepatocyte uptake transporter organic anion-transporting polypeptide 8 in liver parenchyma [ ], and the superparamagnetic iron oxide particles SPIOs , which are sequestered by phagocytic Kupffer cells in the reticuloendothelial system of the liver [ ].
Other targeted agent approaches are at an experimental stage: investigations of ultrasmall SPIOs for imaging macrophage activity in lymph nodes and atherosclerotic plaque have been performed, as has labeling of tumors with monoclonal antibodies conjugated to paramagnetic complexes or superparamagnetic nanoparticles [ ].
However, the sensitivities of these techniques are not currently adequate for clinical applications, and new agents with significantly increased relaxivity targeted to specific tissues or disease processes will be required. One such experimental agent is EPR, a molecule containing four Gd-complexes that binds with good specificity to fibrin, where it demonstrates a relaxivity per molecule approximately 25 times higher than a conventional GBCA at 1.
This agent has also demonstrated good visualization of thrombi in a swine model of pulmonary embolism [ ], and could depict thrombi in the arterial and venous systems and hearts of patients [ , ].
Monitoring Response to Therapy Early information on disease progression and response to therapy has considerable potential benefits for patient management, by promptly highlighting a need to shift therapeutic approaches and by providing cost savings if expensive therapies e. A number of quantitative DCE and perfusion parameters are now considered biomarkers with value for the prediction and monitoring of therapeutic response, particularly to date in the oncologic and cardiologic specialties [ , , ].
For example, in oncology, perfusion mapping as a surrogate measure of blood flow correlates with response to tyrosine-kinase inhibitor therapy in patients with renal tumors [ ], and quantitative kinetic parameters of lesion enhancement at DCE can predict whether triple-negative breast cancer patients will respond to neoadjuvant chemotherapy [ ]. Conclusion The field of CE-MRI has expanded beyond expectations since the approval of the first MRI contrast agent, gadopentetate dimeglumine, in , and it continues to evolve.
New techniques are bringing exciting novel possibilities for MRI, alongside associated clinical challenges. Notes Acknowledgments Sponsorship, article processing charges, and the open access charge for this study were funded by Bayer HealthCare. All named authors meet the International Committee of Medical Journal Editors ICMJE criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published.
Disclosures J Lohrke, T. Frenzel, J. Endrikat and H. Pietsch are employees of Bayer HealthCare. Alves, T.
25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives
Grist, M. Law, J. Lee, T. Leiner, K. Li, K.
Nikolaou, M. Prince, H. C Weinreb and K. Yoshikawa have nothing to disclose. Compliance with ethics guidelines This article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors. Nuclear induction.
Phys Rev. CrossRef Google Scholar 2. Relaxation effects in nuclear magnetic resonance absorption. CrossRef Google Scholar 3. Lauterbur PC. Image formation by induced local interactions: examples employing nuclear magnetic resonance.
CrossRef Google Scholar 4. Image formation in NMR by a selective irradiative process.
11 editions of this work
CrossRef Google Scholar 5. All science is interdisciplinary—from magnetic moments to molecules to men. Les Prix Nobel. The Nobel Prizes Stockholm: Nobel Foundation; Google Scholar 6. Mansfield P. Snap-shot MRI. Google Scholar 7. Damadian R. Apparatus and method for detecting cancer in tissue.
Patent 3,, Feb, Google Scholar 8. FONAR image of the live human body. Physiol Chem Phys.
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Frenzel books to read online.Haase senckenberg. Google Scholar 8. Frenzel Paperback was filled in relation to science. The best strategy for raising relaxivity at high field strength is probably a moderate reversible binding to plasma proteins, a large second sphere of water molecules surrounding the Gd-complex, and an increase in q; however, the benefits of the latter modification should be weighed against any reduction in complex stability. Examples of this concept are experimental Gd complexes covalently bound to albumin, dextran or macromolecules dendrimers , which have shown T1-relaxivities 3—5 times greater than clinically available agents [ , , , ].
The challenges for the adoption of m-health. Apparatus and method for detecting cancer in tissue.
The Nobel Prizes An IRB review of mHealth research must address challenges such as the lack of face-to-face interaction, minor consent, responsibility of data integrity, privacy, security, confidentiality, and the collection of unrelated study data eg, geographical location, personal contacts, Internet searches.
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